The bioactivity of most near-infrared II (NIRII) fluorophores are limited, thereby conflicting the achievement of strong fluorescence and high catalytic activities, due to a lack of free electrons in the method.
and mouse microglia. The outcomes showed the capacity of the clusters to regulate oxidative stress and induce favorable biological activities without toxicity at high concentrations.
The enzyme-mimicking activity of gold clusters. Schematic illustration of the enzyme-mimicking activity of Au22 clusters. The adsorption energy of ABTS•+ on Au22, Au21Cu1-trimer, and Au21Cu1-tetramer clusters, respectively. Time-dependent curves and quantitative results of ABTS•+ of Au22 and Au21M1 clusters. The adsorption energy of O2•− on Au22, Au21Cu1-trimer, and Au21Cu1-tetramer clusters, respectively. Time-dependent curves and quantitative results of O2•− of Au22 and Au21M1 clusters.
In vitro treatment of cisplatin-induced AKI with gold clusters. Schematic diagram of cellular level experiments. HK2 cell viability in the presence of cisplatin with or without treatment of Au22 clusters and Au21Cu1 determined by CCK8 assays . BV2 cell viability in the presence of cisplatin with or without treatment of Au22 clusters and Au21Cu1 determined by CCK8 assays . Fluorescence microscopic images of intracellular ROS and O2•− levels induced by cisplatin with or without gold clusters.
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