Recent patents relating to compositions and methods for targeted editing of nucleic acids
Strategies, systems, reagents, methods and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject; for example, within the human genome. In one embodiment, fusion proteins comprise a Gam protein, a nucleic acid programmable DNA binding protein and a cytidine deaminase.
The base editor can edit bases in DNA, deaminates cytosine into uracil, and has high editing efficiency even if cytosine is positioned at a GpC site or is in a hypermethylated state.Adenosine deaminases that are capable of deaminating adenosine in DNA. Also, fusion proteins comprising a Cas9 domain and adenosine deaminases that deaminate adenosine in DNA.
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