Pregnant women who took over-the-counter pain relievers such as ibuprofen and acetaminophen were at higher risk of experiencing stillbirth, miscarriage, and delivering their babies pre-term, according to a massive new U.K. study.
Researchers in the United Kingdom surveyed records of more than 151,000 women who gave birth in the Aberdeen Maternity and Neonatal Databank between 1985 and 2015. The vast majority of women, over 83%, who were pregnant reported using an over-the-counter analgesic to relieve common symptoms such as joint pain in the first trimester. They studied five common pain relievers — acetaminophen, ibuprofen, aspirin, diclofenac, and naproxen.
Pregnant women are generally discouraged from taking nonsteroidal anti-inflammatory drugs such as aspirin, Advil, and Aleve due to the risk they pose of causing neonatal kidney damage and high blood pressure in the baby's lungs, particularly in later stages of pregnancy. Acetaminophen was especially common, with 55% of the pregnant women the U.K. researchers studied reported using it.
“Different compounds can affect the mother and the fetus in a different way, and their combined use might worsen the risk for offspring ill health,” the U.K. authors said. “This study demonstrates the need for additional research before the field can be confidently directed towards one direction or the other.”
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