Around 1-2% of people taking Paxlovid in Pfizer's clinical trial tested positive for the coronavirus after testing negative. Rebound rates are around 5% among the tens of thousands of people who've taken the drug in real-life settings.
of 13,600 Covid patients, which hasn't been peer-reviewed, 6% had their symptoms rebound in the month following the treatment.
People who continue to test positive may still be contagious, so the CDC recommends that people restart isolation for at least five days if their illness returns.Some disease experts suspect the Paxlovid regimen is too short to clear the virus in certain people. But some people may still have lingering virus in their bodies, particularly if they had high viral loads to begin with or the virus spread to areas that drugs can't easily reach. In that case, symptoms could come back.
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