The trend marks the fourth wave in the US overdose crisis, which began with prescription opioid deaths in the early 2000s and has since continued with other drugs. New UCLA-led research has found that the proportion of US overdose deaths involving both fentanyl and stimulants has increased more t
UCLA research identifies a 50-fold increase in US overdose deaths involving fentanyl and stimulants since 2010, marking a concerning ‘fourth wave’ in the opioid crisis. The rise in polysubstance use presents unique healthcare challenges, with racial minorities disproportionately affected and regional variances in drug combinations.
By 2021, stimulants such as cocaine and methamphetamine had become the most common drug class found in fentanyl-involved overdoses in every US state. This rise in fentanyl/stimulant fatalities constitutes the ‘fourth wave’ in the US’s long-running opioid overdose crisis –the death toll of which continues to rise precipitously.
There are also geographical patterns to fentanyl/stimulant use. In the northeast US, fentanyl tends to be combined with cocaine; in the southern and western US, it appears most commonly with methamphetamine.
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