NFL predictions, picks, and odds for San Francisco 49ers vs Los Angeles Rams. NFL Week 2 betting best bet and game analysis.
Nick Bosa to get a sack — YesRams cornerbacks Derion Kendrick and Cobie Durant are poor defenders who will be exploited by 49ers wideout Brandon Aiyuk, who had 1,015 receiving yards last year.
Aiyuk ended the regular season with three consecutive games of at least 59 receiving yards, headlined by a contest against the Raiders where he hauled in nine catches for 101 yards. He had eight catches for 129 yards last week and should continue to see plenty of targets fromNick Bosa didn't get a sack against the Steelers in Week 1 but he had four QB pressures, which is a good indication that he'll get to the QB soon. Bosa racked up 18.5 sacks last year with 3.
The Rams didn't allow much pressure from Seattle's mediocre pass rush last week but left tackle Joe Noteboom surrendered five sacks and 23 pressures in just six games in 2022. He's also dealing with an ankle injury and while that shouldn't keep him out of the lineup, it will make it even tougher for him to handle Bosa. : Covers may receive advertising commissions for visits to a sportsbook or betting siteThe look-ahead line before Week 1 had the 49ers installed as 6.
The 49ers haven't lost in the regular season since Week 7 of last year and have gone 10-2 against the spread in their last 12 games. The Rams ended last season going 2-9 but they did cover the spread in five of their last seven contests. 49ers coach Kyle Shanahan has gotten the best of Rams coach Sean McVay in recent years even when the Rams were a contender. The Niners have gone 8-1 SU and ATS in the last nine meetings between these rivals.
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