Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless share the 2022 Nobel Prize in Chemistry for discovering an easy way to “click” molecular building blocks together.
Three researchers won the Nobel Prize in Chemistry on Wednesday for their discovery of methods to “click” molecular building blocks together, forming complex molecules that can be used in applications ranging from developing drugs to crafting entirely new materials.
“I’m absolutely stunned,” said Bertozzi when she was reached by phone from the Nobel announcement news conference and told she had won the prize. “I’m still not entirely positive this is real. But it’s getting realer by the minute.” Bertozzi is the eighth woman to win the chemistry Nobel. Clicking in these molecules allows chemists to easily change the behavior of a material. Clickable components can improve a substance’s ability to conduct electricity or repel bacteria or can help it map a DNA sequence.
This basic approach made it possible to attach other molecules. Bertozzi was able to lock glowing fluorescent substances onto cell-surface molecules called glycans and to then use this light to track the movement of glycans on the cell. The process revealed aspects of cell development and ways in which cancer cells progress. Notably, Bertozzi’s bio-orthogonal chemistry has helped researchers develop new types of cancer drugs.
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The Nobel chemistry prize is awarded to 3 people for their work in attaching moleculesMassachusetts native Dr. Carolyn Bertozzi grew up in Lexington and got her undergrad degree at Harvard. Dr. K. Barry Sharpless also has ties here. He studied at Harvard and taught at MIT:
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2 California Scientists Among Trio Awarded Nobel Chemistry Prize for Attaching MoleculesThis year’s Nobel Prize in chemistry has been awarded in equal parts to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for developing way of “snapping molecules together.”
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Three scientists win Nobel Prize for chemistry for 'ingenious' molecule-building tool | CNNCarolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless have won the Nobel Prize for chemistry, for work that has produced 'an ingenious tool for building molecules.'
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Barry Sharpless of La Jolla's Scripps Research wins second Nobel Prize in chemistryHe will share 2022 Nobel in chemistry for his work on 'click chemistry'
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